aldosterone_antags
Table of Contents
aldosterone antagonists
see also:
Introduction
- Competitive antagonists of aldosterone (mineralocorticoids) acting on the receptor which is a soluble cytoplasmic protein thereby inhib. the synthesis of physiologically active transport proteins:
- Na-K exchange in distal tubule & collecting duct → incr. Na excretion, decr. K excretion;
- salivary glands
- colon
- may cause clinical hypoaldosteronism and potentially type IV renal tubular acidosis with hyperkalaemia and volume depletion
Spironolactone:
P/K:
- 70% absorbed, signif. 1st pass metabolism & enterohep. circulation;
- extensive plasma protein bound; Eliminated solely by metabolism to active (canrenone) & inactive (canrenoate) metabolites;
Adverse:
- gynaecomastia, androgen-like effects; minor GIT effects; hyperkalaemia;
Interactions:
- salicylates → decr. tub.secretion canrenone → decr. activity spironolactone;
- high K intake or thiazides+renal impair. → hyperkalaemia;
aldosterone_antags.txt · Last modified: 2010/01/18 03:36 by 127.0.0.1