see also:

• polymyositis (PM)
• dermatomyositis
• rhabdomyolysis
• weakness of the lower limb(s) / weak in the knees
• sepsis / septicaemia

• patients with acute onset generalised aches and pains should be initially worked up to exclude underlying sepsis / septicaemia, even if they are afebrile (consider WCC, CRP, blood cultures, etc) or viraemia such as influenza
• patients who have spent prolonged periods on hard surfaces should have a creatinine kinase (CK) to exclude rhabdomyolysis
• patients on statins may have statin-induced myopathy which typically presents as pain in thighs - these patients have a raised creatinine kinase (CK) and should have their statin medication ceased.

• sepsis / septicaemia
• influenza
• rhabdomyolysis
• statin-induced myopathy
• polymyalgia rheumatica
• serotonin syndrome
• post-exertional:
  • transient lactic acid build up in muscles
  • muscle strain
  • heat illness and heat stroke
  • compartment syndrome
• regional ischaemia:
  • compartment syndrome
  • peripheral vascular disease (PVD or PAD)