zanamivir
Table of Contents
zanamivir (Relenza)
see also:
introduction
- Relenza is supplied in a circular doublefoil pack called a Rotadisk®.
- each Rotadisk contains four regularly spaced doublefoil blisters with each blister containing a powder mixture of 5 mg of zanamivir and 20 mg of lactose.
administration of Relenza via nebuliser for those unable to use the Rotadisk BUT NOT on mechanical ventilators
Use of Relenza in this manner may cause obstruction to mechanical ventilation circuits and may be fatal. Do not use on ventilated patients, and indeed, the Australian Govt announced a safety advisory in Oct 2009 that it does not recommend the use of Relenza in nebulisers or mechanical ventilators
- details provided from information made available by the Canadian Board of Pharmacy
- Zanamivir is a white to off-white powder with a solubility of approximately 18 mg/mL in water. The solubility of lactose is approximately 190 mg/mL in water.
- A 10 mg dose requires the use of two blisters.
children
- “In a kinetic study comparing a single dose of zanamivir 10 mg administered via a nebulizer to children ≥3 months to <5 years to zanamivir 10 mg administration via the Diskhaler to children ≥5 years to ≤12 years, all pharmacokinetic parameters were similar, including AUC0inf, AUC0last, Cmax, T1/2 and Tmax.”
- 10 mg of zanamivir (from a solution concentration 16 mg/mL in NSaline) was mixed with 2 mL of normal saline and given via a nebulizer and mask.
- The solution was nebulized for 10-15 minutes or until “apparent dryness” at an airflow of 5 L/min.
for adults with serious illness
- 16mg of zanamivir (from a solution concentration 16 mg/mL in NSaline) was mixed with 2 mL of normal saline and given via a nebulizer and mask with airflow at 6-7L/min for 10min and dosing was 4 times a day for 5 days.
zanamivir.txt · Last modified: 2009/12/13 23:32 by 127.0.0.1