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somatotropin

growth hormone / somatotropin

see also:

introduction

  • a single chain polypeptide hormone secreted by somatotropic cells within the lateral wings of the anterior pituitary gland
  • secretion is modulated by a wide variety of mechanisms including inhibition by somatostatin
  • prolonged excessive secretion causes acromegaly
    • in addition, excessive levels increases glycation stresses on the liver causing increased liver aging1)
  • see also wikipedia

physiology

  • its main actions are:
    • anabolic
      • increasing height in children and adolescents
      • stimulates the growth of all internal organs excluding the brain
      • increases muscle mass through sarcomere hypertrophy
      • increases protein synthesis
      • increases calcium retention, and strengthens and increases the mineralization of bone
      • promotes energy availability:
        • promotes lipolysis
        • promotes gluconeogenesis in the liver and reduces hepatic glucose uptake
    • stimulates the immune system
somatotropin.txt · Last modified: 2025/11/18 22:08 by gary1

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