somatostatin
see also:
growth hormone / somatotropin
hormones
introduction
a peptide
hormone
produced by the hypothalamus, and from delta cells of pancreas
circulating half life is 2-3 minutes
in the brain, it passes along neuron axons to the pituitary where it:
inhibits secretion of
growth hormone / somatotropin
from the anterior pituitary in a negative feedback loop
inhibits secretion of
thyroid stimulating hormone (TSH)
inhibits secretion of
prolactin
in the GIT, it:
inhibits secretion of gastric hormones such as gastrin, CCK, secretin, motilin, VIP, GIP, enteroglucagon
delays gastric emptying
suppresses release of pancreatic hormones - insulin and glucagon
suppresses the exocrine secretory action of pancreas
octreotide
mimics natural somatostatin pharmacologically