https://ozemedicine.com/wiki/ Wed, 03 Jun 2026 17:19:41 +0000 FeedCreator 1.8 https://ozemedicine.com/wiki/lib/tpl/dokuwiki/images/favicon.ico https://ozemedicine.com/wiki/ https://ozemedicine.com/wiki/doku.php?id=prolongedqtc prolonged QTc see also: * The basics of reading an ECG * patterns of ECGs * torsade de pointes VT * short QTc * LITFL - a case of prolonged QTc with R on T bigeminy leading to torsades * avoid prescribing drugs known to cause prolonged QTc to patients at high risk of, or known to have prolonged QTc! * patients are particularly at risk if they also have bradycardia introduction * the QT interval on the ECG is measured from the start of QRS complex to end of the T wave gary1@undisclosed.example.com (gary1) Tue, 02 Jun 2026 01:18:56 +0000 https://ozemedicine.com/wiki/doku.php?id=ibogaine ibogaine see also: * addiction medicine (alcohol and other substance use) Introduction * ibogaine is a psychoactive alkaloid derived from the root bark of the African shrub Tabernanthe iboga * it has been used in trials for significantly and rapidly reducing cravings for certain substances of addiction such as cocaine, metamphetamine, opioids, but is not currently generally available in Australia. gary1@undisclosed.example.com (gary1) Tue, 02 Jun 2026 01:18:30 +0000 https://ozemedicine.com/wiki/doku.php?id=addiction_medicine addiction medicine (alcohol and other substance use) see also: * addiction medicine - drug and alcohol service providers in Australia * drug dependency * ethanol/alcohol dependence * opiate and opioid dependence * acute pain Mx in drug dependent patients * analgesics index * opiates and opioids * opiate antagonists eg naloxone (Narcan), buprenorphine, naltrexone * metamphetamine / meth / ice * ibogaine * National Drug and Alcohol Research Centre (NDARC) - drug trends bulletin We… gary1@undisclosed.example.com (gary1) Tue, 02 Jun 2026 01:01:30 +0000 https://ozemedicine.com/wiki/doku.php?id=osa obstructive sleep apnoea (OSA) see also: * obesity and weight management * noisy breathing * snoring * physiology of sleep Introduction * characterized by loud snoring followed by periods of silence when breathing stops or nearly stops which usually occurs at least five times during every hour of sleep * affects 2-4% of adults gary1@undisclosed.example.com (gary1) Fri, 29 May 2026 21:43:27 +0000 https://ozemedicine.com/wiki/doku.php?id=sleep sleep see also: * sleep hygiene * physiology of sleep * insomnia * snoring * obstructive sleep apnoea (OSA) * fatigue * stress * Coping with shift work * managing jet lag and your body clock Introduction * sleep is a primary driver of glymphatic clearance removing wastes from the brain * there appears to be a 90% reduction in glymphatic clearance during wakefulness, and twice the amount of protein clearance from the brain intima during sleep - and it appears that gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 14:16:11 +0000 https://ozemedicine.com/wiki/doku.php?id=sleep_physiology physiology of sleep see also: * sleep * sleep hygiene * insomnia * fatigue * shift work * Managing jet lag and your body clock introduction * During a single 24 hour day we have a period of 6-10 hours when we are very sleepy. This is the time when we normally sleep. During the remaining 14-18 hours we are usually awake; however, only a portion of that waking time is suitable for intellectual effort. This period of maximum alertness may last as little as 2-6 hours. We should plan our d… gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 13:43:44 +0000 https://ozemedicine.com/wiki/doku.php?id=snoring snoring see also: * sleep * stridor * wheeze * stertor * obstructive sleep apnoea (OSA) * physiology of sleep Introduction * noise during breathing can be of various types depending upon whether awake or asleep and on where the airway obstruction arises * snoring is a form of stertor which occurs during sleep either as a result of vibrations of nasopharyngeal structures with raised pharyngeal collapsibility or from nasal obstruction gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 13:34:58 +0000 https://ozemedicine.com/wiki/doku.php?id=neurology neurology see also: * neurosurgery * psychiatry and mental health * neuroanatomy * the brain * neurology / acute stroke services at Western Health neurologic examination: * cranial nerve examination * sensory & motor testing including dermatomes, myotomes, reflexes, coordination & balance * sandnsurf.com - Gate's anatomy of the brainstem rules * cognitive testing: * cognition * mental state - delirium vs dementia vs psychosis * AMTS cognitive impairment test * CAM confusion … gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 13:32:19 +0000 https://ozemedicine.com/wiki/doku.php?id=glymphatic_system glymphatic system of the brain see also: * the brain Introduction * discovered in 2012, the glymphatic system is a “pseudo-lymphatic” perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain. gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 08:45:20 +0000 https://ozemedicine.com/wiki/doku.php?id=brain the brain see also: * brain evolution and development * cerebrospinal fluid (CSF) * stroke (CVA) * neurology * consciousness * memory * speech * modelling the brain: * Dec 2023: Uni of Cambridge, UK, announces by using their new concept 3D “spatially embedded recurrent neural networks” (seRNNs) they have created a self-organizing, artificially intelligent system that uses the same tricks as the human brain to solve specific tasks. The seRNNs converged on structural and functional fe… gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 08:44:29 +0000 https://ozemedicine.com/wiki/doku.php?id=sleep_hygiene sleep hygiene see also: * sleep * physiology of sleep * insomnia * fatigue * stress * Coping with shift work * managing jet lag and your body clock * sleep disorders, excessive daytime sleepiness and dangers of driving with its legal ramifications: * Australian Roads * Australasian Sleep Association * perhaps your body clock is set early in life and inherited from your mother as with zebra fish * daylight savings and sleep disruption * caffeine and guarana helps drivers stay a… gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 08:42:41 +0000 https://ozemedicine.com/wiki/doku.php?id=lymphoma_mantlecell mantle cell lymphoma (MCL) see also: * lymphoma * Fact sheet (pdf) * LLS Fact sheet (pdf) * Int J Molecular Sciences 2019 review article (pdf) Introduction * accounts for ~7% of non-Hodgkin lymphoma (NHL) cases * most patients are aged over 50yrs (men have 2-7x risk) * so-called because the tumour cells originally come from the “mantle zone” (the outer edge) of the lymph node gary1@undisclosed.example.com (gary1) Thu, 28 May 2026 07:44:19 +0000 https://ozemedicine.com/wiki/doku.php?id=lymphopenia lymphopenia see also: * full blood examination (FBE) * lymphocytosis * neutropenia Introduction * peripheral blood lymphocyte counts below 1,500/µL * lymphocytes include T cells, B cells (which produce immunoglobulin) and CD8+ Killer Cells - see adaptive immunity Acute lymphopenia * is associated with increased severity of viral infections and need for hospitalisations (eg. gary1@undisclosed.example.com (gary1) Wed, 27 May 2026 19:31:17 +0000 https://ozemedicine.com/wiki/doku.php?id=pot1_mutation POT1 Tumor Predisposition Syndrome (POT1-TPD) see also: * neoplasia / cancer / tumours Introduction * a rare autosomal dominant germline loss-of-function mutations of POT1 (Protection of Telomeres 1) gene (on chromosome 7) which prevents the normal capping and regulation of telomeres and this results in abnormal lengthening of telemores and prevention of normal cell senescence apoptosis. gary1@undisclosed.example.com (gary1) Wed, 27 May 2026 16:59:37 +0000 https://ozemedicine.com/wiki/doku.php?id=neoplasia_aetiology neoplasia / cancer aetiologic factors see also: * neoplasia / cancer / tumours introduction * carcinogenesis modifiable causes * 40% of cancers in adults are thought to be attributable to potentially modifiable lifestyle factors: * cigarette smoking (19% of cases and 29% of cancer deaths) gary1@undisclosed.example.com (gary1) Wed, 27 May 2026 16:57:58 +0000 https://ozemedicine.com/wiki/doku.php?id=sarcoma sarcomas see also: * neoplasia / cancer / tumours Introduction Risk factors * 16-23% of patients with angiosarcoma have inherited POT1 mutation - this is also associated with lymphomas, melanomas, leukaemia gary1@undisclosed.example.com (gary1) Wed, 27 May 2026 16:52:54 +0000