Mx of high TSH

see also:

• hypothyroidism
• Mx of a low TSH

• persistently high TSH with low free T4 suggest primary hypothyroidism
  • free T3 levels don't add much
• persistently high TSH (usually to 5-10IU/L) with normal free T4 suggest subclinical primary hypothyroidism and typical symptoms may be absent.
• low free T4 without elevated TSH levels suggest secondary hypothyroidism due to pituitary disorders
• low free T3 without elevated TSH levels has been called Low T3 syndrome
  • usually also have higher levels of a hormone known as reverse T3
  • appears to be present in less than 20% of CFS and it might play a role in worsening conditions like kidney disease or serious infections
• if cause is not obvious then:
  • high titres of antithyroid antibodies (thyroid peroxidase, antimicrosomal, or antithyroglobulin) indicate an autoimmune cause