Inhibin

see also:

• gynaecology
• follicle stimulating hormone (FSH)
• luteinizing hormone (LH)
• activin

• hormone secreted by luteal cells & also by Sertoli cells of testes.

• the main inhibitory feedback mechanism for pituitary follicle stimulating hormone (FSH) secretion in males and has a major role in regulation of follicle stimulating hormone (FSH) secretion in females
• inhibin downregulates FSH synthesis and inhibits FSH secretion.
  • in females, inhibin is produced in the gonads, pituitary gland, placenta, corpus luteum and other organs
    • FSH stimulates the secretion of inhibin from the granulosa cells of the ovarian follicles in the ovaries. In turn, inhibin suppresses FSH.
    • inhibin B reaches a peak in the early- to mid-follicular phase, and a second peak at ovulation.
    • inhibin A reaches its peak in the mid-luteal phase.
    • inhibin secretion is diminished by GnRH, and enhanced by insulin-like growth factor-1 (IGF-1).
  • in males, inhibin is secreted from the Sertoli cells
    • androgens stimulate inhibin production