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--- vitc [2026/06/10 23:51] – [Mechanisms of action] gary1
+++ vitc [2026/09/21 12:24] (current) – [Mechanisms of action] gary1
@@ Line 25: / Line 25: @@
   ***carnitine production**
   ***helps TET1 epigenetic regulation**
     *vitamin C helps maintain TET activity by donating electrons to regenerate Fe<sup>2+</sup> from Fe<sup>3+</sup> and supplementation may thicken the skin epidermal layer which has become thinned during [[aging]] (([[https://www.jidonline.org/article/S0022-202X(25)00416-6/fulltext|2025: Vitamin C Promotes Epidermal Proliferation by Promoting DNA Demethylation of Proliferation-Related Genes in Human Epidermal Equivalents]]))
+  ***vitamin C is an essential partner to TET2, an enzyme that suppresses cancer cell growth**
+      * 1000mg/d supplementation seems to improve mortality in those with clinical cytopenia of unknown significance (CCUS) or myelodysplastic syndrome (MDS) (([[https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.70549|2026: Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo-controlled trial]]))
   ***may help cognition and reduce dementia risks**
     * the the Rotterdam Scan Study reported that higher vitamin C intake was associated with an 18% lower relative risk (RR) for development of Alzheimer’s Disease(([[https://jamanetwork.com/journals/jama/fullarticle/195058|2002: Dietary Intake of Antioxidants and Risk of Alzheimer Disease]]))