Differences

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--- steatohepatitis [2026/07/02 04:21] – [non-alcoholic steatohepatitis (NASH)] gary1
+++ steatohepatitis [2026/08/04 09:58] (current) – [non-alcoholic steatohepatitis (NASH)] gary1
@@ Line 33: / Line 33: @@
     *arterial hypertension
     *hypertriglyceridemia
-    *chronic PM<sub>2.5</sub> particle exposure (([[https://www.news-medical.net/news/20250205/Study-links-low-levels-of-PM25-exposure-to-liver-damage.aspx]]))
+    *chronic PM<sub>2.5</sub> particle exposure including microplastics such as polyethylene (([[https://www.news-medical.net/news/20250205/Study-links-low-levels-of-PM25-exposure-to-liver-damage.aspx]]))(([[https://www.science.org/doi/10.1126/sciadv.aec8681|2026: Spatial transcriptome mapping identifies Ppara-Anxa2 cross-talk in microplastic-induced hepatotoxicity]]))
     *genetic factors(([[https://egastroenterology.bmj.com/content/3/3/e100218|2025: Yang et al: Steatotic liver disease and cancer: from pathogenesis to therapeutic targets]])):
       * PNPLA3 (I148M, rs738409): the strongest risk allele linked to lipid droplet metabolism dysfunction in hepatocytes and stellate cells, promoting steatosis, fibrosis, and HCC;