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--- periodontitis [2026/07/13 10:43] – [Potential contributory risk to other diseases] gary1
+++ periodontitis [2026/07/30 02:12] (current) – [Potential contributory risk to other diseases] gary1
@@ Line 51: / Line 51: @@
 =====Potential contributory risk to other diseases=====
   ***see also: [[oral_microbiome]]**
+  *periodontitis reprograms bone marrow neutrophils through a Chac2-driven glutathione metabolic pathway, promoting a highly inflammatory N1 state that fuels systemic inflammation(([[https://www.nature.com/articles/s41368-026-00451-6|2026: CHAC2-mediated glutathione metabolic reprogramming drives N1 polarization of bone marrow neutrophils and exacerbates inflammatory comorbidities]]))
+    * chronic inflammatory diseases can affect organs far beyond the original site of inflammation by reshaping immune responses throughout the body, a process known as 'central immune remodeling.'
   *//Str. viridans// forms biofilms in vascular endothelium and appear to be an important factor in the **progression of [[atherosclerosis|atherosclerosis]], [[AMI|heart attacks]], [[hypertension]], chronic mildly raised [[CRP]], cognitive decline, liver disease**(([[https://www.news-medical.net/news/20250409/Gum-disease-linked-to-worsening-liver-health.aspx]]))
   *//Porphyromonas gingivalis// plays a disproportionately large role in causing gingivitis and periodontitis, and seems that it may also play an important role in the development of **calcific aortic valve stenosis** (([[https://newsroom.heart.org/news/bacteria-from-gum-disease-may-cause-inflammation-harden-heart-valves]]))