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--- lumbar_disc_prolapse [2024/11/07 22:32] – [introduction] gary1
+++ lumbar_disc_prolapse [2026/08/07 00:40] (current) – [genetic aetiologies] gary1
@@ Line 98: / Line 98: @@
   *PARK2 gene
     *it appears this gene may be switched off in people with LDD
+  *a zebra fish study suggests intervertebral disc disease may be due to disruptions to how the body handles fat and to a growth-control pathway called mTOR, alongside changes in phosphate handling and vitamin A signalling – all processes linked to mineral buildup in the ligaments which is a precursor to the disease, and bisphosphonates appear to reduce this as well as restricting food intake, or using drugs that dampen fat metabolism (([[https://www.nature.com/articles/s42003-026-10702-1|2026: Targeted modulation of phosphate and lipid metabolism reduces ligament mineralization in col9a1b deficient zebrafish]]))