cachexia
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| cachexia [2026/09/03 03:31] – [Tumor proteins] gary1 | cachexia [2026/09/03 03:31] (current) – gary1 | ||
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| *sensitivity to GDF15 is the cause of [[hyperemesis_gravidarum]] and serum levels can also be 10-100x higher than normal in patients with advanced cancers | *sensitivity to GDF15 is the cause of [[hyperemesis_gravidarum]] and serum levels can also be 10-100x higher than normal in patients with advanced cancers | ||
| - | ====skeletal | + | ====Skeletal |
| *ubiquitin-proteasome system: | *ubiquitin-proteasome system: | ||
| * inflammatory signals massively up-regulate specific E3 ubiquitin ligases (such as MuRF1 and MAFbx), tagging muscle proteins for destruction | * inflammatory signals massively up-regulate specific E3 ubiquitin ligases (such as MuRF1 and MAFbx), tagging muscle proteins for destruction | ||
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| * chronic catabolism impairs the ability of satellite cells to repair and regenerate damaged muscle fibers | * chronic catabolism impairs the ability of satellite cells to repair and regenerate damaged muscle fibers | ||
| - | ====adipose | + | ====Adipose |
| *lipolysis and fat browning: | *lipolysis and fat browning: | ||
| * white adipose tissue undergoes accelerated breakdown (lipolysis) and converts into metabolically active " | * white adipose tissue undergoes accelerated breakdown (lipolysis) and converts into metabolically active " | ||
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| *a 2026 study on mice suggests that lung cancer produces more local prostaglandin E2 which then activates vagal nerve activity via lung neurons which appears to mediate cachexia and this can be **remedied by blocking PGE2 production or blocking the the vagal nerve** (([[https:// | *a 2026 study on mice suggests that lung cancer produces more local prostaglandin E2 which then activates vagal nerve activity via lung neurons which appears to mediate cachexia and this can be **remedied by blocking PGE2 production or blocking the the vagal nerve** (([[https:// | ||
| - | ====anorexia | + | ====Anorexia |
| *reduced intake which cannot match the body's catabolic losses: | *reduced intake which cannot match the body's catabolic losses: | ||
| * profound anorexia from the above mechanisms and metabolic shifts | * profound anorexia from the above mechanisms and metabolic shifts | ||
cachexia.txt · Last modified: 2026/09/03 03:31 by gary1