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troponin

troponin

Introduction

  • troponin is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that is integral to muscle contraction in skeletal muscle and cardiac muscle, but not smooth muscle.
    • Troponin C binds to calcium ions to produce a conformational change in TnI
    • Troponin T binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex
    • Troponin I binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place
  • cardiac I and T subtypes of troponin are sensitive and specific indicators of damage to myocardium and thus are the current main cardiac markers for myocardial injury
  • troponin elevation following cardiac cell necrosis starts within 2–3 hours, peaks in approx. 24 hours, and persists for 1–2 weeks

aetiology of acutely raised troponin I or T levels

"type 1 NSTEMI or STEMI coronary artery events"

"type 2 events"

aetiology of chronically raised troponin levels

troponin.txt · Last modified: 2020/06/07 22:24 by wh