detailed history and exam to search for likely cause and best approach to investigation, in particular:
history of the pain and was there trauma?
could the patient be pregnant? (this will affect analgesia options, radiology, and raise possibility of PE or ruptured ectopic as causes)
is there a history of fevers or chills, cough, SOB, calf pain, dissection risk factors
overseas travel
VTE risk factors
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where is the tenderness?
double check for acute neurology
double check it is not referred pain from abdomen
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immunocompromised, IVDU or recent staphylococcal infection - consider inflammatory markers