osa

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osa [2025/08/14 01:09] – [Social apnoea] whosa [2025/11/13 10:10] (current) – [Adverse effects of OSA] gary1
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     * increased risk for the development of hypertension, cardiovascular diseases, stroke, diabetes, neurocognitive deficits, depression, and mood disorder     * increased risk for the development of hypertension, cardiovascular diseases, stroke, diabetes, neurocognitive deficits, depression, and mood disorder
       * apneas and hypopneas in REM sleep have been found to be linked with non-dipping of nocturnal blood pressure and incident hypertension whereas unrecognized OSA (ie, patient categorized as no OSA because the overall AHI < 10 events/h, but the AHI in REM sleep ≥ 20 events/h) has an independent association with hypertension       * apneas and hypopneas in REM sleep have been found to be linked with non-dipping of nocturnal blood pressure and incident hypertension whereas unrecognized OSA (ie, patient categorized as no OSA because the overall AHI < 10 events/h, but the AHI in REM sleep ≥ 20 events/h) has an independent association with hypertension
 +      * alter cellular exosome secretion and content(([[https://journals.lww.com/cmj/fulltext/2025/10200/exosomes_in_obstructive_sleep_apnea_related.3.aspx|2025: Exosomes in obstructive sleep apnea-related diseases]]))
 +        * altered plasma exosomes trigger endothelial cell aging and dysfunction, accelerating atherosclerosis
 +        * exosomal miR-20a-5p damages hippocampal neurons, worsening cognitive impairment
 +        * adipose tissue-derived exosomes with miR-155 induce insulin resistance
 +        * exosomal miR-421 promotes non-alcoholic fatty liver disease (NAFLD) by inhibiting liver cell pathways
     * may affect your partner's sleep     * may affect your partner's sleep
  
osa.txt · Last modified: 2025/11/13 10:10 by gary1

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