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essential_thrombocytosis

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essential_thrombocytosis [2026/05/10 19:34] – [introduction] whessential_thrombocytosis [2026/05/10 21:03] (current) – [introduction] wh
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   *a [[myeloproliferative_disorders|myeloproliferative disorder]] characterised by a high platelet count of > 600 × 10^3/µL for at least 2 months   *a [[myeloproliferative_disorders|myeloproliferative disorder]] characterised by a high platelet count of > 600 × 10^3/µL for at least 2 months
   *incidence ~ 20 new cases per 1 million population per year   *incidence ~ 20 new cases per 1 million population per year
-  *mainly effects middle aged and elderly+  *mainly effects middle aged and elderly often following a pre-malignant period ([[CHIP]]))
   *similar to primary [[myelofibrosis]], this condition is due to mutually exclusive acquired somatic gene mutations:   *similar to primary [[myelofibrosis]], this condition is due to mutually exclusive acquired somatic gene mutations:
     *40-50% of cases are associated with a mutation in the [[JAK|JAK2 kinase (V617F) gene]]     *40-50% of cases are associated with a mutation in the [[JAK|JAK2 kinase (V617F) gene]]
essential_thrombocytosis.txt · Last modified: 2026/05/10 21:03 by wh

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