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--- dementia [2026/06/11 00:22] – [slowly progressive dementia] gary1
+++ dementia [2026/06/16 09:07] (current) – [slowly progressive dementia] gary1
@@ Line 39: / Line 39: @@
       * long term (12-24 months) use of non-Aβ42-lowering NSAIDs appears to lower risk of all cause dementia as well as lowering AD risk with HR of 0.74 (([[https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.19411|2025: Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk]]))
     *trials will commence in 2019 for an Ultrasound Rx which appears to clear amyloid build up and delay dementia (([[https://qbi.uq.edu.au/dementia-clinical-trial]]))
+    *a 2026 study showed that Cu(ATSM) can increase the abundance of P-gp clearance pumps in a mouse Alzheimer's model, by 24% and over 56 days, reduced toxic amyloid-beta by 42% and improved spatial learning by nearly 44% (([[https://pubs.acs.org/doi/10.1021/acschemneuro.6c00252|2026: Cu(ATSM) Restores Blood–Brain Barrier Abundance of P-Glycoprotein and Improves Cognitive Function in the APP/PS1 Mouse Model of Alzheimer’s Disease]]))
     *early symptoms include:
       *inability in recalling recently observed events