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--- csf_leak [2026/06/18 03:37] – [Mx] gary1
+++ csf_leak [2026/06/18 03:37] (current) – [Mx] gary1
@@ Line 73: / Line 73: @@
       * abducens nerve palsy is a potential complication of skull-base surgery for repair of a CSF leak
   ***if spontaneous leak or high intracranial pressure:**
-    *acetazolamide, 500 mg twice daily for the first week, followed by a lower dose of 250 mg twice daily for the second week, has a high success rate in closing the primary defect in spontaneous CSF leaks
+    *acetazolamide, 500 mg twice daily for the first week, followed by a lower dose of 250 mg twice daily for the second week, has a high success rate in closing the primary defect in spontaneous CSF leaks(([[https://www.ncbi.nlm.nih.gov/books/NBK538157/]]))
       * acetazolamide reduces CSF synthesis by 48%, decreasing the volume and reducing pressure
       * should be administered to patients with spontaneous CSF leaks who exhibit signs of increased intracranial pressure
     *if refractory or particularly high intracranial pressure, ventriculoperitoneal shunt placement can be effective but has relatively high complication rates